Thalassemia and COVID-19: Susceptibility and Severity
نویسندگان
چکیده
Context: COVID-19 results in an imbalance between procoagulant and anticoagulant homeostatic mechanisms that could be complicated with thrombotic events. In β-thalassemia patients, the presence of comorbidities, iron overload, adrenal hypofunction, splenectomy, chronic hypercoagulable state might increase susceptibility to its severity. Evidence Acquisition: The search was conducted PubMed, Web Science, Scopus databases for key terms β-thalassemia/thalassemia until July 2021. Results: survey published observational studies (mostly multicenter case reports) indicated a lower prevalence patients compared general population, as well mild moderate these especially those without comorbidity. β-Thalassemia children were susceptible but less severity adults. There is no report pulmonary embolism events COVID-19; however, coagulation abnormality microembolism have been found patients. Conclusions: Findings interpreted by high hemoglobin F (HbF) levels, advantage hydroxyurea (HU) therapy, chelation therapy However, due low sample size studying mainly young should caution, it still needs more larger confirm findings.
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ژورنال
عنوان ژورنال: Iranian Journal of Pediatrics
سال: 2021
ISSN: ['2008-2150', '2008-2142']
DOI: https://doi.org/10.5812/ijp.119789